- 期刊
- OpenAccess
SIADH as a Paraneoplastic Syndrome of Squamous Cell Carcinoma of the Hypopharynx
並列摘要
Introduction: Hypopharyngeal cancer is an uncommon malignancy, representing only 4.3% of head and neck cancers. It is usually found late in the course, accounting for its high five-year mortality. SIADH has been seen in other squamous cell cancers mainly of the lungs. Case Report: We report a case of profound hyponatremia secondary to SIADH occurring in an elderly Vietnamese man in the setting of a large, well-differentiated squamous cell cancer of the hypopharynx. Conclusion: SIADH is a common occurrence in squamous cell cancer of the lung. It occurs in only 3% of head and neck tumors. The putative etiologies include direct carotid involvement by the tumor, carotid manipulation during operative dissection, and as a side effect of chemotherapy or radiation. In this case, SIADH preceded operative intervention and there was no carotid involvement of the tumor. SIADH is an uncommon occurrence in head and neck tumors despite majority of them being squamous cell cancers. Usual etiologies for SIADH in this setting include medication side effects and involvement or manipulation of the carotid artery. None of these factors were present in this case leading to the conclusion that SIADH was caused by the tumor itself.