Introduction: Mechanical intestinal obstruction with closed loop phenomenon secondary to knotting of the mesentery is an uncommon entity that can rapidly evolve into ischemia of the intestinal segment that forms the knot. It originates with the wrapping of the mobile ileal loop compromising the mesentery in the center of the knot and is an unusual cause of intestinal strangulation. Case Report: We report a case of small bowel gangrene caused by ileo-ileal knotting. Patient underwent emergency exploratory laparotomy and resection of gangrenous small bowel segment with end to end anastomosis. Conclusion: Ileo-Ileal knotting should be considered in the differential diagnosis of acute intestinal obstruction associated with abdominal tenderness and absence of peritonitis. Emergent exploratory laparotomy with high index of suspicion yields optimal results.