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Isolated Plexiform Neurofibroma Presenting as White Lesion of Vulva: A Case Report
並列摘要
Introduction: Neurofibromas commonly involve peripheral nervous system but rarely may involve genital organs such as labia, clitoris, vulva, vagina and cervix. Case Report: We present a case of isolated plexiform neurofibroma of vulva which presented as white lesion of vulva. A tissue biopsy was done and the histopathological analysis-demonstrated plexiform neurofibroma with spindle shaped cells with wavy nuclei and bland nuclear chromatin. The immunohistochemical staining showed strong positivity for S-100 protein which has a strong correlation with neurofibromatosis-1. No systemic sign of neurofibromatosis was found. Conclusion: Plexiform neurofibroma may present as isolated white lesion of the vulva without any systemic involvement in the form of neurofibromatosis. So a tissue biopsy is mandatory for definitive diagnosis of any white lesion of vulva.