Introduction: Shoulder osteoarthritis can cause significant patient morbidity and current conservative treatment is limited. We present a case report of shoulder osteoarthritis treated with photoactivated platelet-rich plasma injections (PAPRP). Case Report: A 62-year-old female was presented with chronic shoulder pain secondary to glenohumeral osteoarthritis. The patient underwent a course of intra-articular glenohumeral PAPRP. Patient outcome measures included the numerical pain rating scale (NPRS), Disabilities of arm, shoulder and hand score (DASH) and patient perceived improvement (PPI). Following treatment the patient reported improvements in both pain and function as measured by the NPRS, DASH and PPI. Repeat imaging showed no evidence of osteoarthritis progression. Conclusion: In this case report, PAPRP injections for the treatment of shoulder osteoarthritis resulted in improvement in all recorded measures of pain and function. Whilst only level 5 evidence, the promising outcome of this single case report highlights the need to further evaluate through more structured controlled trials the efficacy of PAPRP in the treatment of glenohumeral osteoarthritis.