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＂Nigrospora Sphaerica＂ Causing Corneal Ulcer in an Immunocompetent Woman: A Case Report
並列摘要
Introduction: Corneal ulcers secondary to trauma can often pose a clinical challenge. The causative pathogen is at times an unusual and resistant microorganism which may not be identified by conventional laboratory techniques. Case Report: A 45-year-old immunocompetent woman with a history of injury of right eye with a cow's tail was diagnosed to have fungal corneal ulcer. Sporulation of the isolate occurred after prolonged incubation and the pathogen was found to be Nigrospora sphaerica. The number of cases of true infection caused by this fungus amount to only five in available literature. The patient did not improve with medical management using natamycin and ketoconazole and underwent voriconazole therapy. Conclusion: Delayed sporulation of pathogenic fungal isolates may necessitate prolonged incubation and use of multiple sporulation techniques for the purpose of speciation. Uncommon fungi also need to be kept in mind when dealing with an unresponsive/ worsening clinical situation.