Introduction: Abnormal uterine bleeding is a common but complicated clinical presentation that impairs the quality of life in women. Case Report: A reproductive-aged woman presented abnormal uterine bleeding of unknown reason with a heavy bleeding intermenstrual period. By physical examination, laboratory and imaging tests, pregnancy, iatrogenic cause, systemic condition and genital tract pathology were excluded. After high doses of estrogen with oxytocin and intrauterine balloon pipe treatment, the bleeding gradually reduced and stopped. Conclusion: Abnormal uterine bleeding is one of the most common reasons that reproductive-aged women seek health care. In rare complicated cases, however, the causes are difficult to identify which will lead to a delay in treatment and significant loss of the blood. Keywords: Abnormal uterine bleeding, Hemostasis, Reproductive-aged women