- 期刊
- OpenAccess
攝食高劑量鋁對大白鼠生長、生殖及其體內鋁含量之影響
Effects of Aluminum Ingestion on Growth, Reproduction and Tissue Aluminum Content in Rats
摘要
The purpose of this study was to investigate the effects of aluminum (A1) ingestion on growth, reproduction and tissue A1 contents in female Sprague-Dawley rats. Weaning female rats were fed A1 at dosages of 0 (Control), 0.5 (Low-A1) and 2g/1 (High A1) as aluminum nitrate. Treatment continuing throughout maturity, gestation and parturation except mating. Aluminum content of serum and organs of rats were determined. Right brains of rats were sectioned and stained for examination of the aluminum deposition and possible pathological effects. A significant decrease in the weight gain of the animals receiving 2g/1 of aluminum was observed (P＜0.05). However, dams of High-A1 group were probably not malnourished because there was no significant difference in intake per unit body weight and feed efficiency among three groups. Nevertheless, there was a significant decrease of water intake with increasing of Aluminum intake (p＜0.05). Serum, lung and spleen aluminum content also higher in High-A1 group than that in other groups (P＜0.05). Mean-while, Neonates of High-A1 group had smaller litter size (P＜0.05). It was concluded that dietary aluminum could be absorbed and resulted elevation of the aluminum levels of serum, and organs in dams. The placenta probably could partially protect the fetus from A1. On the other hand, the High-A1 group dams which ingested as much of twenty times of aluminum as control group, were influenced by aluminum on growth and reproduction. Therefore, it was suggested that high amount of aluminum should not be ingested especially during gestation.
並列摘要
The purpose of this study was to investigate the effects of aluminum (A1) ingestion on growth, reproduction and tissue A1 contents in female Sprague-Dawley rats. Weaning female rats were fed A1 at dosages of 0 (Control), 0.5 (Low-A1) and 2g/1 (High A1) as aluminum nitrate. Treatment continuing throughout maturity, gestation and parturation except mating. Aluminum content of serum and organs of rats were determined. Right brains of rats were sectioned and stained for examination of the aluminum deposition and possible pathological effects. A significant decrease in the weight gain of the animals receiving 2g/1 of aluminum was observed (P＜0.05). However, dams of High-A1 group were probably not malnourished because there was no significant difference in intake per unit body weight and feed efficiency among three groups. Nevertheless, there was a significant decrease of water intake with increasing of Aluminum intake (p＜0.05). Serum, lung and spleen aluminum content also higher in High-A1 group than that in other groups (P＜0.05). Mean-while, Neonates of High-A1 group had smaller litter size (P＜0.05). It was concluded that dietary aluminum could be absorbed and resulted elevation of the aluminum levels of serum, and organs in dams. The placenta probably could partially protect the fetus from A1. On the other hand, the High-A1 group dams which ingested as much of twenty times of aluminum as control group, were influenced by aluminum on growth and reproduction. Therefore, it was suggested that high amount of aluminum should not be ingested especially during gestation.