以化學治療藥物Epirubicin治療血液惡性疾病之臨床報告

Epirubicin in Combination Chemotherapy for Hematological Malignancy

黃偉修(Wei-Shou Hwang) ； 李偉政(Wy-Chan Lee) ； 于國平(Kuo-Pin Yu) ； 張俊彥(Jang-Yang Chang)

《Journal of Medical Sciences》 8卷1期 (1987/07) Pp. 35-39

摘要

化學治療藥物Epirubicin是一種與Doxorubicin（Adriamycin）功能相似但結構不同的藥物，經動物及人類臨床試驗證實具有高度的抗癌療效。在治療血液惡性疾病7例患者中，我們以Epirubicin結合其他化學藥物給予治療。其中有5例獲得完全緩解，2例獲得部分緩解，僅有1例對此化學治療無效。其主要之副作用為禿髮、骨髓抑制作用及輕微的嘔吐，治療的7例患者中沒有產生心臟毒性之副作用。

關鍵字

心臟毒性 ； 血液惡性疾病

並列摘要

Epirubicin is a doxorubicin analogue presenting a high degree of activity against experimental animal tumors as well as human tumors. We conducted a clinical trial of epirubicin in treating patients with hematological malignancy. Five patients with Non-Hodgkin's lymphoma were treated by CEVP. One patient of relapsed Hodgkin's disease was treated by EBV. One patient with relapsed ALL was treated by EVP. Five of the 7 patients had complete remission (71.4%) after treatment. Two patients had partial remission. One patient had no response to treatment at all. The major side effects were alopesia, bone marrow suppression and mild degree of vomiting. No cardiac toxicity was found in any case.

並列關鍵字

Epirubicin ； Cardiotoxicity ； Hematological malignancy