- 期刊
- OpenAccess
Nifedipine血中濃度與療效間之關係
Relationship between Therapeutic Efficacy and Blood Concentration of Nifedipine
摘要
本研究係採用「高效率液相層析系統」配合「氧化性電化學偵測器」，偵測慢性高血壓病患於服用降血壓藥物Nifedipine（10 mg/tab）後，其血中藥物濃度變化時程與患者血壓和心跳變化間之相互關係。研究結果顯示，雖然Nifedipine本身遇光易分解，但由於處理過程時間短，並且採用避光容器和措施，因此，極少有其光解產物干擾其確實分析濃度，而且此藥物的回收率大於百分之八十，足見此藥物的分析系統準確性極高。此外，研究結果顯示病患服用Nifedipine（10 mg/ted）後，其血中濃度變化時程和降血壓作用，確實有相當關係性，即其降血壓作用隨著血中濃度的升高而加強。同時，血中藥物濃物到達尖峰時間時，其降血壓作用也最明顯。此外，Nifedipine在本研究的高血壓患者中，其血中最高濃度反應不一，最低者為4 ng/ml，最高者為52 ng/ml。而且，Nifedipine降低舒張壓的作用大於降低收縮壓的作用，由此可知，Nifedipine降低血壓的原因，主要是舒張周邊血管所致。以上的資料，可提供臨床醫師們使用此藥物治療高血壓患者時之參考，並可儘量減少副作用的產生。
並列摘要
A rapid, specific, reliable high-performance liquid chromatographic systemic with electrochemical detection was used to measure the concentration of nifedipine in plasma. The recovery of nifedipine is higher than 80%, therefore, this indicates that the method which we used in this study was reliable. Furthermore, the relationship between therapeutic efficacy and blood concentration of nifedipine after a single dose of 10 mg/tab was observed in eight hypertensive patients. Results demonstrate that blood pressure was rapidly decreased after the oral administration of nifedipine in hypertensive patients. Meanwhile, the plasma nifedipine concentration was relatively correlated both with the fall in diastolic pressure and systolic pressure. Furthermore, the antihypertensive effects of nifedipine on diastolic pressure was greater than on systolic pressure. In conclusion, this method is highly available to monitor the plasma concentration of nifedipine and to predict the therapeutic and toxic effects of nifedipine.