- 期刊
- OpenAccess
Myelodysplastic Syndromes: A Study of Internuclear Bridging and in Vitro Growth Patterns
造血分化不良症候群：對核間橋樑與體外骨髓培養之研究
摘要
Thirty-three patients with F AB-classified primary myelodysplastic syndrome (MDS) were investigated for in vitro growth of colony-forming units for myeloid precursors (CFU-C) and microscopic searching for internuclear bridging (INB). We found that 45% of MDS had INB was neglected in the past, and those with very low CFU-C count had a tendency towards worse prognosis. Combining low colony count and the absence of INB, we found that they had a higher acute leukemia transformation rate and that the changes might be conductive to the prognostic evaluation in MDS.
並列摘要
Thirty-three patients with F AB-classified primary myelodysplastic syndrome (MDS) were investigated for in vitro growth of colony-forming units for myeloid precursors (CFU-C) and microscopic searching for internuclear bridging (INB). We found that 45% of MDS had INB was neglected in the past, and those with very low CFU-C count had a tendency towards worse prognosis. Combining low colony count and the absence of INB, we found that they had a higher acute leukemia transformation rate and that the changes might be conductive to the prognostic evaluation in MDS.