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原發性蝶竇癌-病例報告

Primary Sphenoid Sinus Cancer-A Case Report

摘要


原發性蝶竇癌乃一罕見的惡性腫瘤。由於解剖位置特殊,早期症狀不明顯,在發現時往往都已是局部廣泛性侵犯,所以預後不佳。本文報告,三軍總醫院15年來,第1例原發蝶竇癌,患者為51歲男性,主訴頭疼,視力模糊已有2個月之久。理學檢查發現左眼有多枝眼球運動神經麻痺的現象,電腦斷層攝影顯示出腫瘤位於蝶竇處並侵犯到左側後篩竇、左眼眶後部、左側視神經管及左側海綿竇等位置。由組織病理切片證實為未分化癌,經體外放射線照射後,症狀獲明顯改善,但治療結束後3個月,於同側下頷淋巴腺及多處骨骼發生轉移,曾先後接受姑息性放射線照射與化學治療,1年後病患死亡。

並列摘要


Primary sphenoid sinus cancer is a rare malignacy. The early symptoms were always subclinically and most of the cases were found to have locally advanced invasion before treatment. We identified a male with presentation of headache and blurred vision for 2 months. Physical examination revealed neuro-ophthalmologic symptoms of left eye. CAT scan disclosed a contrast enhanced soft tissue mass occupied the sphenoid sinus with invasion to left side of pterygopalatine fossa, posterior ethmoid sinus, optic canal, posterior orbital fossa and cavernous sinus. It was biopsy-proven undifferentiated carcinoma. Split-course radiotherapy with a total tumor dose of 7000 cGy in 42 fractions was given to tumor bed over a period of 66 days. Split for 11 days was done when tumor dose reached 4000 cGy. Nearly total regression of primary tumor which was identified from CAT scan and marked improvement of the symptoms were noted at the end of irradiation. But metastases over left submandibular and multiple skeletal regions developed 3 months after the completion of radiotherapy. He died of disease 7 months later. The interval from diagnosis to death was just for 12 months.

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