- 期刊
- OpenAccess
利用半乳醣排除能力評估肝硬化病患的預後
Prognostic Value of Galactose Elimination Capacity in Patients with Cirrhosis Based on a Serial Determination
摘要
In recent years considerable interest has been paid to dynamic liver function tests, and to measure liver cell mass quantitatively. A better quantification of liver function than qualitative measure might help to predict the prognosis.The present prospective study was based on the data of sixteen patients with liver cirrhosis. Among them, 13 were male and 3 were female with a mean age of 49±17.2 yr. Ten cases were related to hepatitis B virus. Galactose elimination capacity (GEC) and galactose single point method (GSP) were used for measuring residual liver finction every three to six months. A total of 65 determinations were made with 4.3±1.54 times for each patient. Average follow-up time was 2.5±0.32 yr. The result showed that the GEC and GSP values of these patients highly significantly increased with time (P＜0.001). Also significantly positive correlations were observed between GEC, GSP, serum alanine aspartate aminotransferase (AST), and albumin (P＜0.001). The values of GEC, GSP were also significantly correlated with globulin, bilirubin, serum alanine aminotransferase (ALT)(P＜0.05). According to the Child-Pugh classification. 10 liver cirrhosis patients were classified as A, 3 as B, and the rest 3 as C. The GEC values of group C were 3.95, 2.44, 3.8 mg/min/kg and all the three cases died within 3 years.It is suggested that liver cirrhosis with HBV positive patients in Child class A, the disease is not progressive in the present study. Whether th GEC＜4 mg/min/kg indicates a poor prognosis needs to be further evaluated.
並列摘要
In recent years considerable interest has been paid to dynamic liver function tests, and to measure liver cell mass quantitatively. A better quantification of liver function than qualitative measure might help to predict the prognosis.The present prospective study was based on the data of sixteen patients with liver cirrhosis. Among them, 13 were male and 3 were female with a mean age of 49±17.2 yr. Ten cases were related to hepatitis B virus. Galactose elimination capacity (GEC) and galactose single point method (GSP) were used for measuring residual liver finction every three to six months. A total of 65 determinations were made with 4.3±1.54 times for each patient. Average follow-up time was 2.5±0.32 yr. The result showed that the GEC and GSP values of these patients highly significantly increased with time (P＜0.001). Also significantly positive correlations were observed between GEC, GSP, serum alanine aspartate aminotransferase (AST), and albumin (P＜0.001). The values of GEC, GSP were also significantly correlated with globulin, bilirubin, serum alanine aminotransferase (ALT)(P＜0.05). According to the Child-Pugh classification. 10 liver cirrhosis patients were classified as A, 3 as B, and the rest 3 as C. The GEC values of group C were 3.95, 2.44, 3.8 mg/min/kg and all the three cases died within 3 years.It is suggested that liver cirrhosis with HBV positive patients in Child class A, the disease is not progressive in the present study. Whether th GEC＜4 mg/min/kg indicates a poor prognosis needs to be further evaluated.