Hydrocolloid occlusive dressing is well document on burn wound management. The alternative application of hydrocolloid occlusive dressing is in the management of pressure ulcers. In our study, thirteen cases of stage III and IV pressure ulcers were completed with hydrocolloid occlusive dressing and persisted for three weeks. Seven cases were completed in the whole. According to the data of using hydrocolloid occlusive dressing, we find that the hydrocolloid occlusive dressing can get simpler wound dressing and better wound healing than traditional dressing in the management of stage III and IV pressure sores. The hydrocolloid occlusive dressing is also a good alternative method in the treatment of pressure sores in high risk group.