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Test Heterogeneity of the Lupus Anticoagulant (LA): Comparison of Various LA Tests in 102 Cases of Systemic Lupus Erythematosus
狼瘡性抗凝物（LA）試驗之差異性：在102個全身性紅斑性狼瘡病例中比較不同的LA試驗
摘要
用五種不同之試劑包括Staclot PNP, Staclot LA,PTT-LA和兩種dilute Russell's viper venom time tests，偵測102位全身性紅斑性狼瘡（SLE）病人之lupus anticoagulant。這五種試驗有不同的陽性率，範圍為4到9%，而且病人在不同的試驗有不同的結果。若以病人有兩項或兩項以上的LA試驗呈現陽性，則作為陽性時，在本研究中有8%的SLE病人為LA陽性。在這五種LA試驗，DVV試驗與LA-Screen & LA-Confirm有最高的相關性（k=0.648）。而與任何其他四種試驗有最高相關性的試驗則為Staclot LA，其相關性為（k=0.864）。由於LA試驗結果的差異性，如果病人只有一種LA試驗為陽性，則要小心診斷是否有LA。
並列摘要
Five commercial kits including Staclot PNP, Staclot LA, PTT-LA, and 2 dilute Russell's viper venom time tests for detecting lupus anticoagulant were determined in 102 patients with systemic lupus erythematosus (SLE). The 5 coagulation tests had different positive rates ranging from about 4 to 9%, and the patients might have different result by using different test. If we regarded a patient with two or more positive LA tests as being positive, 8% of the SLE patients in our study were LA positive. Among the 5 LA tests, the highest correlation was between DVVtest and LA-Screen & LA-Confirm (k=0.648), and the test having the highest correlation with the remaining other 4 tests was Staclot LA (k=0.864). The consistency of LA tests and anti-cardiolipin antibody test was good. Due to the heterogeneity of the results of LA tests, the diagnosis of the presence of LA in a patient should be carefully made if only one LA-positive test was obtained.