如何為高血壓病患選擇合適的NSAID類止痛藥？

非類固醇類抗炎藥（NSAID）會阻斷前列腺素的生成，造成血管阻力的上升，而促成血壓的上升，NSAID對腎功能的影響亦會造成血壓升高。許多研究已證明NSAID會促成血壓升高，綜合分析這些資料可知，NSAID對平均動脈壓的影響約略5 mmHg。長期服用NSAID對心血管疾病的危險性，在老年人和高血壓病患較高。NSAID中各類藥物對血壓的影響並不相同，indomethacin, naproxen影響較大。

關鍵字

高血壓；止痛藥；非類固醇類抗炎藥

並列摘要

NSAID cause the elevation of vascular resistance and then the blood pressure via blocking the synthesis of prostaglandins. Besides, the effect of NSAID on the kidney will cause the elevation of blood pressure, too. Many studies had demostrated the NSAID will cause the elevation of blood pressure, and according to the meta-analysis of these data, the rise of mean arterial pressure is about 5 mmHg. The risk of cardiovascular and cerebrovascular complication seemed to be higher on the old-age and the p't with hypertension. Not all NSAIDs are equal as far as their effect on blood pressure is concerned. The interference seemed to be larger with indomethacin and neproxen.

並列關鍵字