抗鬱劑誘發之躁症發作

Manic Episodes Induced by Antidepressants

陳信任(Hisn-Jen Chen) ； 楊聰財(Tsung-Tsair Yang) ； 陸汝斌(Ru-Band Lu) ； 張敏(Ming Chang)

《Journal of Medical Sciences》 21卷1期 (2001/02) Pp. 1-8

摘要

抗鬱劑（antidepressant）的使用可以明顯縮短重鬱發作病程、改善身體及精神症狀。但是自60年代以降，關於使用抗鬱劑是否會誘發躁症或輕躁症發作以及縮短再次發作間期（cycling length）乃至由於誘發雙極症之快速循環（rapid cycling）發作的報告便層出不窮。由於缺乏系統性的回顧相關的文獻，這個問題一直沒有一個明確的結論，同時也缺乏大型、前瞻性、系統性的研究足以證明或推翻此可能性。故本文一方面回顧整理正反方之文獻，一方面也討論過去研究之優、缺點及研究限制並尋找進一步研究的方向。

關鍵字

抗鬱劑 ； 躁症 ； 躁鬱症 ； 單極型重鬱症 ； 雙極性情感疾患

並列摘要

The use of antidepressants has the remarkable effect of significantly reducing both the duration and symptoms of major depressive episodes. However, there were numerous reports and general consensus since the 60s indicating that the use of antidepressants can induce a manic/hypomanic episode, shortening the cycling length in bipolar disorders, or inducing a rapid-cycling bipolar disorder. We reviewed the data in the literature on this topic. But we were surprised to find that there were no clear conclusions, nor were there large scaled, prospective studies. Thus, in the current paper, we sorted out from the past literature the evidence supporting and against this point of view. We also pointed out the limitations of previous studies, and proposed several possible solutions for further research.

並列關鍵字

antidepressants ； manic ； hypomania ； bipolar affective disorder ； major depressive disorder