The superior vena cava (SVC) syndrome is an emergency and potentially fatal event. Malignancy is the most common etiology of the syndrome and catheter-induced thrombotic SVC syndrome is rare. We report a 45-year-old woman who presented with SVC syndrome induced by a Port-A catheter. She had a history of adenocarcinoma of the rectum with resection of the tumor and had completed adjuvant chemotherapy via a Port-A catheter 7 months previously. Computed tomography of the patient's chest revealed a low-attenuation thrombus around the Port-A catheter in the SVC and left brachiocephalic vein. The clinical symptoms improved gradually after sequential management, including anticoagulant therapy, thrombolytic therapy and removal of the catheter.