Chromoblastomycosis is a chronic persistent fungal infection which affects the skin and subcutaneous tissue. It is an occupation-associated fungal infection and exhibits a high prevalence rate in tropical and subtropical regions. Targeting the chronic progression of granulomatous inflammation, the single-treatment modality usually encounters difficulty and is accompanied by serious side effects. Herein we reported a patient who had multiple well-circumscribed erythmatous hypertrophic plaques with several satellite papules on the right elbow for 5 years and the diagnosis of chromoblastomycosis was confìrmed by skin biopsy and fungal culture. The lesions were eradicated with the combined administration of oral itraconazole and liquid nitrogen cryotherapy for half a year. This case report is meant to suggest the use of combinative therapy for patients with intractable chromoblastomycotic infection.