- 期刊
可控降解速率之鎂合金材料設計與製備
Alloy Design and Preparation of Controllable Degradation Magnesium Alloy
摘要
金屬材料機械特性優異，適用於生物可降解醫用結構型植入物。金屬植入物因體液腐蝕，植入物逐漸損失，導致材料腐蝕產物進入到生物體中而可能對生物體產生危害，故生物可降解醫用植入物需兼顧金屬材料的生物相容性、力學性能及腐蝕性。鎂鋅鈣合金降解後的產物對生物體而言為可代謝且無毒，唯一的缺點為其降解速率難以控制。為了控制鎂鋅鈣合金的降解速率，常藉由添加第四種元素，如鋁元素或稀土元素等，但這類元素將伴隨著合金降解會殘留於生物體中或造成代謝不良的負面影響，因此在臨床應用上有安全的疑慮。本研究採用高合金混合熵之鎂鋅鈣合金製備鎂合金降解材，並採粉末冶金製程製備，以避免巨觀偏析劣化材料，再經由熱壓成錠後擠製成棒材，經加工後完成可降解鎂骨釘製備。
並列摘要
Metal is suitable for biodegradable medical structural implants with excellent mechanical properties. Metal implants are gradually lost due to body fluid corrosion, causing material corrosion products to enter the organism and may cause harm to the organism. Therefore, biodegradable medical implants need to take into account the biocompatibility. The products of magnesium-zinc-calcium alloy degradation is non-toxic to organisms. The only disadvantage is that the degradation rate is difficult to control. In order to control the degradation rate of magnesium-zinc-calcium alloys, the fourth element is usually added, such as aluminum or rare earth elements. However, these elements will remain in the organism or cause negative effects of poor metabolism along with the degradation of the alloy. Therefore, there are safety concerns in clinical applications. In this study, magnesium alloy degradable materials are prepared by high-alloy mixed entropy magnesium-zinc-calcium alloys, and are prepared by powder metallurgy processes to avoid macro-segregation and degraded materials. The materials are hot pressed into billets, then extruded into bars, which are then machining into Degradable magnesium bone nails.