摘要
自主神經系統在於引起心房顫動扮演重要的角色，迷走神經性心房顫動係指副交感神經興奮所引起的心房顫動。其作用機轉主要是經由活化乙醯膽鹼鉀離子通道(I(下标 KACh))，在心房造成不均勻地不反應期與動作電位縮短，形成再進入迴路(reentry)因而誘發心房顫動。交感神經興奮會使迷走神經性心房顫動更容易發生。副交感神經興奮會使肺靜脈異常放電更容易發生，因此肺靜脈異常放電也可能是引起迷走神經性心房顫動的重要原因。心臟本身疾病會改變迷走神經對於心房細胞的正常作用，可能也是引起心房顫動的原因。臨床的診斷仍主要有賴於詳細病史詢問，去迷走神經(vagal denervation)是否能治療迷走神經性心房顫動仍有爭議，特異性乙醯膽鹼鉀離子通道阻斷劑未來可能是治療方式的選擇之一。
並列摘要
The autonomic nerve system plays an important role in atrial fibrillation (AF). Vagal AF refers AF (generally paroxysmal) arising in contexts of enhanced parasympathetic tone. Heterogeneity of refractoriness and action potential abbreviation resulting from spatially variable parasympathetic enhancement of the acetylcholine-dependent K(superscript +)-current (I(subscript KACh)) underlie vagal AF. Adrenergic influences may also contribute to the occurrence of vagal AF. Cholinergic stimulation may enhance ectopic firing from pulmonary vein cardiomyocytes, which potentially contribute to the occurrence of vagal AF. On the other hand, underlying heart disease modulates cholinergic regulation of atrial myocytes. Careful history taking in AF patients is important for vagal AF management. Vagal denervation may play a role in the efficacy of ablation procedures, but the results are conflicting. Specific I(subscript KACh) channel blockers may become the treatment of choice in the future.