自從Jaffe在1935年提出骨樣骨瘤這一病名後,它的臨床症狀以及病理變化已廣被接受。近八年來三軍總醫院及馬偕紀念醫院共經歷了31位病例。由病歷記載及X-光片上之分析,發現此病好發於年青人。年齡由11歲到62歲均有,平均22.8歲。男女別為2比1。主要症狀是疼痛,佔100%,尤其是夜間疼痛,阿司匹靈可暫時解痛者51.6%。一般X-光片上顯示特殊之肥厚及鞏膜化變化,但核心之發現機率有61.3%。故常須伴以其他輔助檢查,諸如Laminography,Tc99m之核子掃瞄或血管攝影。手術為最好的治療方法,完全切除核心是手術的目標。有30例接受手術,29例症狀完全消除(96.7%),只有一例經兩次手術(一次在別家醫院手術)後,繼續疼痛,病人拒絕接受再一次的手術,經七年的追縱,疼痛繼續存在。手術切之標本經病理檢查能找到核心者有18例,其他12例中11例雖未找到核心,但症狀也完全消失。
Osteoid osteoma has been recognized as a specific clinicopathological entity since 1935 when Jaffe first described the disease. In the past eight years, the authors totally encountered 31 cases of osteoid osteoma, and these cases usually involved young adults. The patient’s age ranged from 11 to 62 years old with an average of 22.8. The lower limbs were the most fre-quently affected, and the cardinal symptom was pain or night pain which was cited by 100 percent of the patients. The pain usually can be relieved by aspirin (51.6%). Roentgenogram films revealed a radiolucent center surrounded by a zone of radiopacity. The nidus was visibly demonstrated in 61.3% of the plain films. Other auxillary diagnostic tools, such as the laminography, the Tc 99mm bone scan, the CT scan and the angiography, should also be utilized to demonstrate the nidus. Surgical excision of the nidus was the treatment of choice. Thirty of thirty-one patients had surgical excision, and 29 of these cases (96.7%) experienced complete relief of pain. The only case that failed to respond to surgery had no demonstrable nidus on the roentgenographic films and had been operated once before. The nidus was confirmed histologically in 18 out of the 30 surgical patients. In eleven cases, however, the staff failed to histologically identify the nidus even though the pain had completely subsided after surgery.