We tried to define the importance of lesion location and size in determining the possibility of pathological fracture of subtrochanter. Biomechanical test was set using pork femorae. Sixty pork femorae were used. Lesions were made with special saw, bur and drill, in various sizes over various locations of pork subtrochanter, i.e., the compression side, the tension side, the anterior neutral side, and the posterior neutral side. MTS was used to create compression force over the femoral head to make the fracture so that the effect of lesion location/size to the development of fracture could be decided. Except in the 8 cases with lesion over the compression side which got fracture through the defect area, all the other cases got fracture over the subcapital area which did not relate to the defect area. The lesion sizes of those 7 cases were significantly larger (p<0.05) than those of the other 5 cases with lesion over the compression side. The location (the compression side) and size of the lesions both are important in determining the possibility of pathological fracture.