- 期刊
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紅麴納豆激酶調節血脂功能之評估
Evaluation of the Effects of Nattokinase Combined with Red Yeast Supplementation on Blood Lipid Profiles
摘要
在許多醫學及臨床上的研究，納豆具有溶解血栓、抗高血壓、預防癌症、預防骨折等許多促進健康的效果，而紅麴因可抑制膽固醇生合成之重要酵素已證實可降低血脂質濃度。本實驗係以納豆激酶加紅麴膠囊為投予物，共招募50位高脂血症者參加，並分成兩組，為一倍劑量組和二倍劑量組，進行10週的三階段實驗，此三階段將分別為2週調整期、6週實驗期及2週排空期。由統計結果得知，受試者補充納豆激酶加紅麴膠囊三週後即可以顯著地降低血清總膽固醇和低密度脂蛋白膽固醇濃度，一倍劑量組和二倍劑量組的血清總膽固醇濃度分別顯著減少9.7%和6.5%，且血清低密度脂蛋白膽固醇濃度分別顯著下降10.5%和10.6%，對血清三酸甘油酯和高密度脂蛋白膽固醇濃度及低密度脂蛋白氧化延遲時間反應均沒有影響。因此，每日補充納豆激酶加紅麴膠囊可降低血脂質濃度，進而可減緩動脈粥狀硬化之發生或進展，以預防心血管疾病的發生。
並列摘要
In much medical and clinical research, strong fibrinolytic activity, anti-hypertension, and cancer and bone fracture prevention were demonstrated using the ”natto bean”. Red yeast (monascus purpureus) can inhibit enzymes that are involved in cholesterol biosynthesis. The aim of this study was to investigate the hypolipidemic action of nattokinase combined with red yeast in mildly hyperlipidemic patients. Fifty subjects were divided into 2 groups, and they received either a low or high dose. The duration of this experiment was 10 weeks, including 2 weeks of washout, 6 weeks of supplementation, and 2 weeks of washout. Fasting blood was collected before and after the 3 periods of the experiment. Total cholesterol declined by 9.7% in the low-dose group and by 6.5% in the high-dose group (p＜0.05), and serum low-density lipoprotein cholesterol levels dropped by 10.5% in the low-dose group and by 10.6% in the high-dose group (p＜0.05) after 6 weeks. No changes in serum triglyceride or high-density lipoprotein cholesterol levels, or the low-density lipoprotein oxidization lag time were noted. In conclusion, nattokinase combined with red yeast supplementation had beneficial effects on blood lipids profiles.