- 期刊
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慢性腎臟病患者代謝症候群與腎功能之探討
Metabolic Syndrome and Renal Function of the Chronic Kidney Disease Patients
摘要
代謝症候群(metabolic syndrome, MS)是慢性腎臟病(chronic kidney disease, CKD) 的重要罹病因子。因此，本研究將探討CKD第三、四期患者腎功能指標與代謝症候群之關係。收集估計腎小球濾過率(estimated glomerular filtration, eGFR) 15-60 mL/min/1.73 m^2 者之年齡、性別、腎功能指標尿毒素(血清尿素氮(blood urea nitrogen, BUN) 、肌酸酐、硫酸吲哚酚(in-doxy sulphate, IS)、對-甲酚硫酸鹽(p-cresol sulphate, PCS) 與尿酸值) 及代謝症候群指標(腰圍、收縮壓、空腹血糖、三酸甘油酯及高密度脂蛋白膽固醇)等資料進行分析。結果顯示CKD第三至四期患者之代謝症候群指標(腰圍、血壓、血糖及三酸甘油酯)皆高於正常值，第四期患者之血清尿毒素(BUN、肌酸酐、IS與PCS值)顯著高於第三期患者。血清BUN、肌酸酐、IS、PCS之間呈顯著正相關(p ＜ 0.05)，且同時與eGFR 呈顯著負相關(p ＜ 0.05)。收縮壓與BUN、肌酸酐、IS和阿S皆呈顯著正相關性。肌酸酐分別與HDL-C值、白蛋白、總蛋白皆呈顯著負相關性(p＜0.05)，尿蛋白與BUN、肌酸酐、IS、PCS皆呈顯著正相關性( p ＜ 0.05)。結果顯示，代謝症候群與CKD患者腎功能惡化有關。
並列摘要
Metabolic syndrome (MS) is an important factor that increases the morbidity of chronic kidney disease (CKD). The present study investigated MS and the renal function of CKD patients. The estimated glomerular filtration rate of patients was 15~60 ml/min/1.73 m^2, and their age, gender, uremic toxins (blood urea nitrogen (BUN), creatinine, indoxyl sulfate (IS), p-cresol sulfate (PCS), and uric acid), and metabolic syndrome indicators (waist circumference, systolic blood pressure, fasting glucose, triglycerides, and high-density lipoprotein cholesterol (HDL-C)) were analyzed. Results showed that the body mass index, body fat percentage, visceral fat, and metabolic syndrome indicators (waist circumference, blood pressure, blood sugar, and triglycerides) of CKD stage 3 and 4 patients were higher than normal. The systolic blood pressure was significantly positively correlated with BUN, creatinine, IS, and PCS (0＜0.05). Creatinine was significantly negatively correlated with HDL-C, albumin, and total protein, Urinary protein was significantly positively correlated with BUN, creatinine, IS, and PCS. BUN, creatinine, IS, and PCS showed significant positive correlations between each other. These results show that MS is related to kidney deterioration of CKD patients.