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Increased Glomerular and Extracellular Malondialdehyde Levels in Patients and Rats with Focal Segmental Glomerulosclerosis
局部腎絲球硬化症病人及大白鼠腎絲球及細胞外液之Malondialdehyde增加
並列摘要
Evidence suggests an increase in oxidative stress in uremic patients. As glomerulosclerosis is the prerequisite for uremia, whether the oxidative stress already exists early is not known. In this study, we measured the plasma and urinary levels of malondialdehyde (MDA), the end product of lipid peroxidation, and we assessed the immunoreactivity of MDA and superoxide dismutas (SOD) in glomeruli of patienets and rats with primary focal segmental golmerulosclerosis(FSGS) and compared our findings to those of minimal change disease (MCD) and normal controls (NC). Our results showed that plasma MDA level was significantly increased in FSGS patients that in both MCD patients and normal controls. The urinary MDA level was also significantly increased and was significantly correlated with plasma MDA level in FSGS patients. The immunostaining for glomerular MDA and SOD were significantly higher in FSGS patients than in either MCD patients or NC, and was also significantly higher in puromycin aminonucleoside (PAN)-induced FSGS rats that in MCD rats. Glomerular MDA leel was significantly correlated with the degree of golmerulosclerosis in FSGS patients. Our data suggest that oxidative stress occurs early before the onset of renal failure, and may play an important role in the pathogenesis of glomerulosclerosis.