- 期刊
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Colchicine Possibly Related Hepatotoxicity and Neutropenia in a Renal Failure Patient
秋水仙素使用在慢性腎臟衰竭病人上可能相關的肝毒性以及中性球缺乏症
摘要
秋水仙素時常被使用在痛風性關節炎的治療上。其副作用包括腹瀉、白血球低下、神經肌肉病變、腎衰竭等。因使用秋水仙素而引起的肝毒性曾經被報導過但是個案非常稀少，本文報導一位七十歲接受腹膜透析的慢性腎臟衰竭病人，因痛風性關節炎發作而服用秋水仙素，一個星期後病人出現食慾不振、嘔吐、腹瀉的情形，接著因意識混亂收住院治療。實驗數據顯示病人有中性球低下、血小板低下和肝功能損害的情形；門診用藥除秋水仙素之外並無其他肝毒性藥品的使用。病毒性肝炎檢驗包括A型肝炎病毒、B型肝炎病毒、C型肝炎病毒、巨細胞病毒、和EB病毒皆呈陰性反應。經停用秋水仙素後肝功能逐漸恢復正常，中性球低下的情形則經顆粒球刺激素的注射後回復正常標準。病人於住院兩週後出院，之後在門診追蹤治療一年其肝功能皆維持正常。
並列摘要
Colchicine has various manifestations of intoxication and is hazardous in chronic renal failure patient. Herein, we report a 70-year-old chronic renal failure patient on continuous ambulatory peritoneal dialysis (CAPD) who suffered from an episode of disturbance of consciousness, neutropenia, thrombocytopenia and impairment of liver function after colchicine administration. The hepatitis and conscious level improved after colchicine withdrawal, the neutropenia was managed successfully by granulocyte colony-stimulating factor injection. Hepatotoxicity, a rare complication induced by colchicine may develop in chronic renal failure patients with maintenance dosage.