Splenic abscess is relatively rare and may he easily missed. It is mostly replace with commonly encountered in immunocompromised patients, such as patients with end-stage renal disease (ESRD) on long-term dialysis, particularly those with concomitant diabetes. In these patients, occult infections may have non-specific and atypical presentations. Patients usually present with unexplained fever and are susceptible to infection by unusual organisms which might cause delays in diagnosis and treatment. We present a diabetic patient with ESRD on long-term hemodialysis who developed persistent fever and left pleural effusion. He was eventually found to have splenic abscess due to an unusual pathogen, Serratia marcescens.