IgA Nephropathy Associated with Ankylosing Spondylitis

Kuo-Hua Lee ； An-Hang Yang ； Wu-Chang Yang ； Der-Cherng Tarng

《Acta Nephrologica》 28卷2期 (2014/06) Pp. 103-106

https://doi.org/10.6221/AN.2014007

並列摘要

Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy, which characteristically results in fusion of the spine and sacroiliac joints. AS can be accompanied by extraarticular manifestations in cardiovascular, pulmonary, neurologic and renal diseases. We herein describe a stable AS patient receiving anti-TNFα. therapy who developed unexplained microscopic hematuria and nephrotic syndrome. Laboratory examinations showed elevated serum immunoglobulin A (lgA) and renal biopsy demonstrated IgA nephropathy. Under immunosuppressive therapy with low-dose steroid and mycophenolate mofetil (MMF) for 6 months, the proteinuria almost remitted completely and renal function remained stable. IgA nephropathy was considered correlated with the pre-existing AS. Anti-TNFα. therapy may also play a role in the exacerbation of IgA nephropathy. This report alerts clinicians to stay watchful for concurrent IgA nephropathy in patients with AS, especially under anti-TNFα. therapy. Corticosteroid combined with MMF is an effective therapeutic regimen for IgA nephropathy in this case report.

並列關鍵字

ankylosing spondylitis ； anti-TNFα therapy ； IgA nephropathy ； mycophenolate mofetil ； nephrotic syndrome

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