Osteocytes Work as Both Regulator and Target of PTH and Vitamin D

Bing-Han Li ； Li Zuo

《Acta Nephrologica》 29卷2期 (2015/06) Pp. 58-70

https://doi.org/10.6221/AN.2015009

並列摘要

Osteocyte has recently emerged as an important modulator in bone-remodeling and one of the most participants in chronic kidney disease-mineral bone disorder (CKD-MBD). Through secreting fi broblast growth factor 23 (FGF23), osteocyte is able to infl uence the production of parathyroid hormone (PTH) and active vitamin D, whose disorder were considered as essential promoters of CKD-MBD. Meanwhile, PTH and active vitamin D could also act on osteocyte and regulate FGF23 in turn, forming a feedback loop among FGF23, PTH and active vitamin D. This review started with a brief summary about the role of osteocyte in three aspects of CKD-MBD: biochemical disorder, bone abnormality and vascular calcifi cation. Then, current available evidences about the involvement of osteocyte in mutual regulation between FGF23, PTH and active vitamin D were reviewed.

並列關鍵字

chronic kidney disease-mineral bone disorder ； fi broblast growth factor 23 ； parathyroid hormone ； vitamin D