- 期刊
To Integrate Point-of-Care and Laboratory Automation System of BNP Testing
BNP檢測在POCT和自動化軌道系統間之整合
摘要
This study compares the BNP correlation between point-of-care (POC) system and the automated laboratory system. Each system owns their unique characteristics. POC system is a global trend aiming to obtain patient data in short turnaround time (TAT), but automated system has high throughput and high quality performance. According to the results, Triage^® BNP performs good correlation between Triage^® MeterPro (POC system) and Beckman^® DxI600 (Beckman BNP = 1.095 xTriage BNP- 20.85, R=09938). This means that we can diagnose emergency patients by in a short TAT, then monitoring the heart failure inpatients by Beckman system (true TAT: 24.7 mins vs. 38.3 mins). In addition, we also investigate the clinical performance of BNP and NT-proBNP on Triage^® system. The total agreement between BNP and NT-proBNP was 86.8% (positive agreement is 100%, negative agreement is 79.5%). It should be note that some non-HF patients show elevated NT-proBNP results. It demonstrates that there might be some factors cause the false positive and worth to do the further investigation.
並列摘要
美國心臟醫學會建議可以使用利鈉胜肽(Natriuretic peptide)因子的檢測幫助心衰竭診斷，如: BNP和NT-proBNP。目前市面上有許多BNP和NT-proBNP的商品化檢測試劑，包含了床邊檢測系統(Point-of-Care testing, POCT)和自動化實驗室系統。兩種系統各有其獨特的優點，例如: POC系統具有很短的報告時效(turnaround time, TAT)；自動化系統則有高運載量和高效能的特性。根據本研究結果，Triage^® BNP在Triage^® MeterPro (POCT)和Beckman^® DxI600 (自動化系統)間具有良好的相關性(Beckman BNP = 1.095 xTriage BNP- 20.85, R=09938)。因此，我們可以利用其不同的系統特性，先使用Triage® BNP進行快速診斷(TAT=24.7分鐘，較自動化系統TAT=38.3分鐘快速)；對於確診為心衰竭而入院的病人，再利用自動化系統進行追蹤檢測。此外，由於Triage^®系統也能執行NT-proBNP的檢測，在本實驗中也進行了BNP和NT-proBNP的臨床效能比較。結果顯示，BNP和NT-proBNP的一致性為86.8%(陽性一致性為100%，陰性一致性為79.5%)。值得注意的是，有部分非心衰竭的病人出現NT-proBNP數值升高的情況，暗示著可能有某些因子會造成NT-proBNP偽陽性，值得我們未來進一步探討。