- 期刊
Helicobacter Pylori Infection and Esophageal Motility in GERD Patients
胃食道逆流性疾病患者幽門螺旋桿菌感染與食道蠕動關係之探討
摘要
幽門螺旋桿菌感染與胃食道逆流性疾病之間關係在最近幾年還是有爭議性的議題。目前已知胃食道逆流性疾病與食道蠕動異常有關。本研究的目的主要要探討胃食道逆流性疾病患者幽門螺旋桿菌感染與食道蠕動異常是否相關。在106位進入研究胃食道逆流性疾病患者中，有86人完成資料收集。其中29人有幽門螺旋桿菌感染(33.7%)，比一般台灣成年人約60%盛行率爲低。食道蠕動異常在有幽門螺旋桿菌感染患者及沒有幽門螺旋桿菌感染患者間，並無顯著差異。而且患者有無幽門螺旋桿菌感染在食道酸鹼值小於4，及食道胃酸清除率上並無差異。我們的結論是雖然無效率食道蠕動會增加胃食道胃酸逆流，但幽門螺旋桿菌感染並不影響食道蠕動。
並列摘要
The relationship between Helicobacter pylori and gastroesophageal reflux disease (GERD) has been a subject of great dispute in recent years. Motility abnormalities of the esophageal body associated with gastroesophageal reflux disease are well known. This study aimed to evaluate the association between H. pylori infection and motility abnormalities in GERD. In this prospective study, 106 patients with GERD were recruited and divided into three groups according to results of esophageal manometric abnormality evaluation. These included patients with normal results (group 1), non-specific esophageal motility abnormality (group 2), and ineffective esophageal motility (group 3). Finally, data from 86 of 106 GERD patients were available for evaluation. Seven patients were excluded because of failed manometric study; thirteen patients were excluded because of incomplete 24-hour esophageal pH records. Diagnosis of H. pylori infection was made in 29 of 86 patients (33.7%). Incidence is significantly lower than in the general adult population (approximately 60% in Taiwan). The differences in esophageal motility abnormality between HP(+) (14 [24.6%] in group 1, 20 [35.1%] in group 2, and 23 [40.4%] in group 3) and HP(-) patients (6 [20.7%] in group 1, 14 [48.3%] in group 2, and 9 [31%] in group 3) was not significant. No significant differences were shown in esophageal fraction time pH＜ 4, and esophageal acid clearance in patients with and without HP infection. We conclude that although ineffective esophageal motility is associated with increased gastroesohageal acid reflux, Helicobacter pylori infection does not affect esophageal motility.