RBF interpolation is a recent meshless interpolation method. It has a very easy form, no correlation with the space dimensions, and is also isotropy. The shape function obtained by RBF has δ function property, so can easily satisfy the essential boundary condition, and their derivatives of the shape function are much easier to obtain compared to that of the moving least square shape function. RBF interpolation accuracy is also found very high. In the EFGM method based on RBF of this paper, the shape function is constructed using the RBF interpolation, and the system equation is discretized by Galerkin weak form. This method is used to solve the bending of plates on the elastic foundation. Some results of numerical examples were given to demonstrate that the proposed method is more effective by comparing with other methods. It is a promising method in engineering.