This article presents the structural safety assessment and erection method research of setting up a full-size temporary bridge for disaster relief in the indoor exhibition area of the National Science and Technology Museum. The erection of full-size bridges in indoor exhibition halls is a very challenging task. The study establishes a numerical structural model of the full-scale bridge and the exhibition building. Then to ensure the safety of the structure of the premise, the extended design of bridge structure and the safety assessment of the demonstration erection and the exhibition building are conducted in this paper. The analysis result includes the load impact factor, the seismic evaluation, and the structural component stress state. When erecting the exhibits, due to the limited space of the indoor exhibition hall, the proper construction equipment and methods must be selected according to local conditions. The conclusions and suggestions compiled in this study can provide relevant references for the structural safety assessment and selection of appropriate construction equipment and methods for constructing real-size bridges in confined spaces in the future.