Pathogenesis and Therapy of Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

EB病毒相關之鼻咽癌之致病機制與治療

林相如(Hsiang-Ju Lin) ； 林榮寵(Jung-Chung Lin)

《中華民國癌症醫學會雜誌》 20卷1期 (2004/03) Pp. 1-17

https://doi.org/10.6588/JCOS.2004.20.1.1

摘要

鼻咽癌是一種根源於上皮細胞之腫瘤，它好發於特殊族群與地區，尤其是中國南方、香港、和東南亞國家包括台灣、新加坡、馬來西亞、印尼、越南等國家。然而在歐美之白人鼻咽癌是罕見的。鼻咽癌的成因與EB 病毒之感染有極密切的關連。本文先從病毒學與生物學的觀點提供EB病毒感染之特性，探討引起鼻咽癌的致病因子，如EB病毒感染、環境因子、以及遺傳基因等，並進一步闡述這三個因子間之相互作用之分子機制。最後探討目前對鼻咽癌的診斷指標、放射線與藥物治療，以及最新的免疫與基因治療的發展近況等。

關鍵字

EB病毒 ； 鼻咽癌 ； 病理機制 ； 治療 ； 診斷

並列摘要

Nasopharyngeal carcinoma (NPC) is a tumor of epidermal origin with endemic distribution among well-defined ethnic groups and geographic regions. NPC is rare among European and North American Caucasians, but it is one of the most common cancers in southern China, Hong Kong, and Southeast Asian countries including Taiwan, Singapore, Malaysia, Indonesia and Vietnam. Its close association with Epstein-Barr virus (EBV) makes it a model for viral carcinogenesis in humans. This article will first provide an overview on the virology and biology of EBV infection and discuss the etiologic factors identified for NPC such as EBV, environmental risk factors and genetic factors. The evidence for the role of EBV and its potential interplay with environmental and genetic factors in the carcinogenic process of NPC will be reviewed. The last section will discuss the diagnostic markers, current status of therapy including radio- and chemotherapy and move toward introducing the cytotoxic T-cell targeting immunotherapy and the development of potential therapeutic gene therapy of NPC.

並列關鍵字

EBV ； NPC ； pathogenesis ； therapy ； diagnosis