Synthesis and Antiplatelet Activity of 1-Substituted Benzyl-2-(5-Hydroxymethyl-2-Furyl)Benzimidazoles

蔡勝忠(Sheng-Chung Tsai) ； 連金城(Jin-Cherng Lien) ； 鄧哲明(Che-Ming Teng) ； 郭盛助(Sheng-Chu Kuo)

《The Chinese Pharmaceutical Journal》 52卷2期 (2000/04) Pp. 79-90

https://doi.org/10.7019/CPJ.200004.0079

摘要

無資料

關鍵字

Benzimidazoles ； Antiplatelet activity

並列摘要

5-Acetoxymethyl-2-furfural (1) was condensed with o-phenylenediamine (2) in the presence of cupric acetate to afford 2-(5'-hydroxymethyl-2'-furyl)- benzimidazole (3) as the major product and 1-(5'-hydroxymethyl-2'-furyl) methyl-2-(5”-hydroxymethyl-2”-furyl)benzimidazole (4) as a minor product. The former product was subsequently reacted with benzyl chlorides to yield the target 1-substituted benzyl-2-(5' -hydroxymethyl-2 '-furyl)benzimidazoles (9-12).
Compared to our previously discovered I-benzyl-2-(5'-hydroxymethyl 2'-furyl)indazole (YC-l), the target compounds exhibited similar but weaker preferential inhibition of platelet aggregation induced by selected inducers.