Conformational Preference of Several Diaryl Ketone Derivatives Required for Antiplatelet Aggregation

李權芳(Chyuan-Fang Lee) ； 毛志民(Pili Chih-Min Mao) ； 周志忠(Tz-Chong Chou) ； 徐令儀(Ling-Yih Hsu)

《The Chinese Pharmaceutical Journal》 53卷4期 (2001/08) Pp. 191-198

https://doi.org/10.7019/CPJ.200108.0191

並列摘要

Several diaryl ketone derivatives such as 2-thienyI2’-methoxyphenyl ketone (C53), 2-furyl 2’-hydroxyphenyI ketone (C73), and 2-thienyI 2’-hydroxyphenyl ketone (C85) possess significant antiplatelet aggregation activity. The conformational features of these three active diary ketone derivatives were analyzed using the grid scan search method to find common conformations that might he responsible for their antiplatelet aggregation activity.

並列關鍵字

Diaryl ketone derivatives ； Antiplatelet aggregation activity ； Conformational analysis