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Anti-Viral Effects of Active Compounds from Antrodia camphorata on Wild-Type and Lamivudine-Resistant Mutant HBV

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Niu-Chang-Chih, which is the fruiting body of Antrodia camphorata, is a folk medicine that has traditionally been used in Taiwan for treating food and drug poisoning, liver disease, and cancer. By using HBV producing cell line as an in vitro model system, we found that Niu-Chang-Chih displays anti-HBV effects on both wild-type and lamivudine-resistant mutants. The active compounds responsible for the anti-viral activities of Niu-Chang-Chih were further investigated and identified by anti-HBV assay directed fractionation. Specifically, out of the ten pure compounds isolated from Niu-Chang-Chih which includes one biphenyl, four ergostanes, and five lanostanes derivatives, 2,2',5,5'-tetramethoxy-3,4,3',4'-bis(methlylene-dioxy)-6,6'-dimethyl-biphenyl was positively identified as the single active compound responsible for the anti-viral effects on both wild-type and lamivudine-resistant mutant HBV.

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賴巧憶(2013)。椴木栽培牛樟芝子實體中三萜類活性成分 Antcin K藉由誘導人類肝癌細胞粒線體及內質網壓力調節之細胞凋亡達到抑癌效果〔碩士論文,國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2013.02107
潘日鴻(2009)。大型樟芝發酵液對肝癌細胞Hep G2生長抑制之探討〔博士論文,國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2009.02229
陳乙菘(2008)。深層培養生產具有維護肝臟功能之樟芝發酵產物〔博士論文,國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2008.01362
黃子寧(2008)。樟芝發酵液揮發性成分變化與其抑制肝癌活性之關係〔碩士論文,國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2008.00068

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