Caisson disease or decompression sickness is recognized to be due to the liberation of the gases previously dissolved in body liquids under increased pressure. Rapid reduction in ambient pressure may cause the forma-tion and growth of gas bubbles within supersaturated body liquids and tissues, resulting in damage of the central nervous system, cardiorespiratory system and the limbs. We presented a 37-year-old male who suffered from Caisson disease one year prior to admission. Neurological examination revealed a syndrome of hemisec-tion of the spinal cord or Brown-Sequard syndrome, manifest with prominent pyramidal tract signs and loss of vibratory sensation on the left lower limb, and lossof superficial and temperature sensation on the right lower limb below the level of about T 10. Myelography and spinal CT disclosed thoracic cord atrophy. Lesion ca not be explained by the vessel distribution of spinal cord. We thus suggested that the spinal cord involvement in the present case was possibly related to a mechanism othan than vascular occlusion.