Pulmonary function and the oxygen partial pressure of arterial (PaO2) were measured in 42 patients with interstitial lung disease (ILD) before and after the examination of bronchoalveolar lavage (BAL), 7 non-smokers without ILD as control group. The result showed that %Vc and FEV 1.0% significantly decreased from 74.33% to 63.5% and from 72.16% to 65.23% respectively, and PaO2 decreased from 10.32 Kpa to 8.38 Kpa, Pulmonary function and PaO2 were affected by BAL in patients with ILD.