- 期刊
Lansoprazole-containing Triple therapy on Helicobacter Pylori Associated Gastric Ulcers
含有lansoprazole之三合一療法對具有幽門螺旋菌感染的胃潰瘍之療效
摘要
幽門螺旋菌在消化性潰瘍扮演著致病原的角色，清除此菌可降低潰瘍復發，但是目前並無一理想治療方案，質子幫補抑制劑加上抗生素的治療法漸被重視。本文報告1995年一月至十一月間，30個幽門螺旋菌陽性的胃潰瘍病人接受新三合一療法(lansoprazole 30 mg bid, charithormycin 250 mg qid, amoxicillin 500 mg qid)之結果。以此三合一療法治療二週，治療結束後四星期時，24 到接受再評估，胃潰瘍的癒合率為70.8%(17/24)，合併潰瘍縮小者則有91.6%(22/24)；潰瘍的延遲癒合與其大小的顯著的相關，與幽門螺旋菌的抹續存在並無相關；幽門螺旋菌的清除率為66.7%(16/24)；20%(6/30)的病人發生副作用(腹瀉、掉髮、失眠、口腔潰瘍、噁心、口乾、口麻、苦味感)，但大多可被接受。此方案對潰瘍癒合及幽門螺旋菌的清除有效，但要提高清除率則需注意病人遵囑性及細菌抗藥性。(慈濟醫學1996; 8: 191-196)
並列摘要
Many regiment have been tried to eradicate Heliccobacter pylori (Hp) in duodenal and gastric ulcers. Lansoprazole, a new proton pump inhibitor, is effective as adjuvant therapy for Hp eradication. In this study, we evaluated the efficacy of a new triple therapy for Hp associated gastric ulcers containing two weeks of treatment with lansoprazole (30 mg bid),clarithromycin (250 mg qid), and amoxicillin (500 mg qid). Thirty patients were enrolled, of whom 24 completed the study. Four weeks after completion of the regiment, follow up endoscopy revealed ulcer healing in 91.6% (22/24) of patients, with complete healing in 70.8%(17/24). The Hp eradication rate was 66.7%(16/24). Delayed healing of the ulcers was significantly associated with the size of ulcer , but not with persistence of Hp. Six of 30 (20%) patients experienced side effects, including diarrhea, alopecia, insomnia, an oral ulcer, nausea, dry mouth, numbness, and bitter sensation. In conclusion, lansoprazole triple therapy is effective for Hp eradication in gastric ulcers. For a higher eradication rate, patient compliance and drug resistance should be further studied.(Tzu Chi Med J 1996;8: 191-196)