- 期刊
Betaxolol Versus Propranolol for the Control of Tachycardia of Hyperthyroidism
Betaxolol 和Propranolol 在治療甲狀腺機能亢進症引起之心博過速的比較
摘要
目的：甲狀腺機能亢進症是甲狀腺疾病中很常見且重要的疾病之一。主要治療藥物是抗甲狀藥物和乙型感神經抑制劑。Propranolol已經廣泛使用於甲狀腺機能亢進症症狀的控制，而betaxolol是具心臟選擇性的乙型交感神經抑制劑，已用於治療高血壓和穩定心絞痛，但過去沒有用在甲狀腺機能亢進症之文獻報告。本研究目的在評估兩者對於甲狀腺機能亢進症中心率脈控制的差異。病人與方法：我們設計一回溯性研究，並收集132個過去未曾接受治療之甲狀腺機能亢進症病患，包含108個女性和24個男性。分成betaxolol和propranolol兩組並比較效用，和觀察其副作用。比較治療後第一週、第二週、第四週的心跳速率。結果：在一般醫師使用的治療劑量下，使用betaxolol一週後可達到最大效果，而propranolol需使用四週才可達到相似效果。結論：由於betaxolol具心臟選擇性，比較不易有傳統乙型交感神經抑制劑之併發症，且每日只要服用一次，在治療甲狀腺機能亢進症，是一個好的選擇。
並列摘要
Objective: Betaxolol is a long-acting highly selective β-blocker. To the best of our knowledge, there no report about the use of betaxolol in hyperthyroidism. The aim of this study was to elucidate the effect of betaxolol versus propranolol, a short-acting, non-selectiveβ-blocker, for the control of tachycardia of hyperthyroidism. Patients and Methods: We did a retrospective study on 132 untreated patients with typical clinical symptoms, signs of hyperthyroidism, and abnormal thyroid function tests. They were divided into 2 groups according to whether they were given propranolol or bataxolol. Heart rates were recorded at 1.2. and 4weeks from the date of initiation of the medication. Results: The betaxolol group showed better results than the propranolo group of a decreased heart rate at doses prescribed by physicians in the outpatient after 1 and 2 weeks. No difference existed between these 2 groups after 4 weeks. There were no betaxolol-related side effects reported during the present study. Conclusions: Betaxolol is effective and has quick action for the control of tachycardia of hyperthyroidism, and may be used in addition to antithyroid drugs for treating patients with hyperthyroidism.