- 期刊
Risperidone-Related Unilateral Rubral Tremor in a Manic Patient-A Case Report
理思必妥治療躁症所誘發之單側肢體紅核顫抖症－病例報告
摘要
紅核顫抖症是一種少見的運動疾患，它的發生通常和中腦的病變有關。其特徵主要為低頻率的顫抖出現在靜止狀態、肌肉收縮產生動作時以及維持固定姿勢時。抗精神病藥物引發之顫抖症通常為巴金森氏顫抖且通常出現在雙側肢體，引發紅核顫抖且僅於單側肢體之病例並未曾被報告。我們報告第一例年輕躁症個案使用抗精神病藥物理思必妥治療，產生單側肢體紅核顫抖症。其症狀的產生與其原本未發現之單側中腦病灶及使用理思必妥有關。當停用理思必妥後，單側肢體紅核顫抖症狀逐漸緩解。此病例提供我們臨床經驗：以治療劑量之理思必妥治療躁症，對原本腦部有器質性因素之個案需小心使用以降低此類副作用之產生。
並列摘要
Rubral tremor is a rare movement disorder that occurs typically with midbrain damage. The main features of this tremor are its low frequency, irregular rhythm, presence at rest, and acceleration during posture and active movement. Antipsychotic agent-induced tremors are usually bilateral parkinsonian tremors. We found no previous reports of unilateral rubral tremor in the literature. A 23-year old man had unilateral rubral tremors as a result of a midbrain lesion plus risperidone exposure for treatment of manic symptoms. After we stopped the use of risperidone, the tremor became less apparent and then disappeared. This case highlights the importance of being aware of this rare complication in susceptible patients receiving risperidone treatment.