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摘要


乳酸中毒(D-lactic acidosis)是一種不常見但容易被忽略的酸中毒,會造成高陰離子隙的代謝性酸血症(high anion gap metabolic acidosis)。D乳酸中毒會發生在小腸切除或小腸吸收不良的病人,尤其是在口服大量的碳水化合物(carbohydrate)之後。常會有運動失調,步態不穩與意識改變等症狀。治療主要是停止口服碳水化合物,使用可殺死產酸菌的抗生素和靜脈輸液。由於大部分的實驗室無法檢測D乳酸,因此臨床醫師的高度警覺對於診斷是很重要的。本篇文章主要回顧D乳酸中毒之機轉,臨床表現,診斷與治療。

並列摘要


D-lactic acidosis is a kind of uncommon high anion gap metabolic acidosis and may be easily overlooked. D-lactic acidosis occurs in patients with small bowel resection or malabsorption after high carbohydrate loading. Ataxia, gait disturbance and altered mental status could be found. Most laboratories do not perform the test to measure D-lactate and clinician's alertness is important for making the diagnosis. Treatment includes withholding enteral intake of carbohydrate, oral anbiotics against acid-producing bacteria and IV fluid. This article reviews the mechanism, clinical manifestations, diagnosis and managements of D-lactic acidosis.

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