D-lactic acidosis is a kind of uncommon high anion gap metabolic acidosis and may be easily overlooked. D-lactic acidosis occurs in patients with small bowel resection or malabsorption after high carbohydrate loading. Ataxia, gait disturbance and altered mental status could be found. Most laboratories do not perform the test to measure D-lactate and clinician's alertness is important for making the diagnosis. Treatment includes withholding enteral intake of carbohydrate, oral anbiotics against acid-producing bacteria and IV fluid. This article reviews the mechanism, clinical manifestations, diagnosis and managements of D-lactic acidosis.