疑似amiodarone引起肺毒性之案例：個案報告及文獻回顧

Suspected Amiodarone Induced Pulmonary Toxicity: Case Report

彭姿蓉(Tzu-Rong Peng) ； 吳大圩(Ta-Wei Wu) ； 鐘雪文(Hsueh-Wen Chung) ； 蘇文麟(Wen-Lin Su)

《內科學誌》 27卷1期 (2016/02) Pp. 39-43

https://doi.org/10.6314/JIMT.2016.27(1).05

摘要

Amiodarone為第三類抗心律不整藥，在許多案例曾被報告很多副作用，其中以肺毒性為最嚴重，甚至可能併發急性呼吸窘迫症候群(acute respiratory distress syndrome，ARDS)，且amiodarone引起之ARDS將近有50%致死率。本案例為長期使用低劑量amiodarone (每日200mg)，而疑似發生肺臟毒性，呼吸困難，經由回顧案例所有病史以及用藥史，仍無法排除為amiodarone所引起之藥物副作用，期望藉此案例報告，能讓醫療人員了解此藥物引起肺臟副作用之機轉與建議採取相關措施，以維護病人用藥安全。

關鍵字

副作用 ； 肺毒性

並列摘要

Amiodarone is classified as a class III antiarrhythmic agent for both atrial and ventricular arrhythmias. Amiodarone has been found to be associated with variety of adverse effects in some case report. The most serious of those is pulmonary toxicity, which may even cause acute respiratory distress syndrome (ARDS), and ensued fatality rate is close to 50 percent. We presented a case had pulmonary toxicity and dyspnea symptoms whom received long-term low dose amiodarone (200mg per day). The literature reviews offer the theorized pathophysiology, therapeutics and monitor recommendations of amiodarone induced pulmonary toxicity to find adverse reaction earlier

並列關鍵字

Amiodarone ； Aderse effect ； Lung toxicity