摘要
反覆性風濕症（palindromic rheumatism）是風濕科門診常見的疾病，臨床特徵為關節或關節附近軟組織的急性發炎腫痛，症狀會不定期反覆發作，且發作的部位不固定，通常每次都侵犯1-2個關節，症狀持續數小時或數天後就自行完全消失，即便反覆多次發炎卻不會對關節或骨頭造成任何破壞。反覆性風濕症的確切病因及致病機轉目前仍不清楚，研究顯示此症可能是一個重疊症候群（overlap syndrome），具有兩種機轉：自體免疫（autoimmune）和自體發炎（autoinflammatory）。值得注意的是，少部分反覆性風濕症病患將來可能進展為全身性自體免疫疾病，其中又以類風濕性關節炎（rheumatoid arthritis）最為常見。近年來有許多研究探討此症與類風濕性關節炎之間的關係，希望藉由血清免疫檢查及超音波影像特徵找出高風險患者，並找到有效治療藥物來防止進展成類風濕性關節炎。
並列摘要
Palindromic rheumatism (PR) is a clinical entity characterized by multiple, recurrent attacks of arthritis and/or periarticular inflammation without residual joint damage. The clinical characteristics are very typical and the diagnosis of PR is usually relatively easy for the rheumatologist but may be more difficult for other clinicians. PR may preclude the onset of some systemic autoimmune disease, especially rheumatoid arthritis (RA). The definite etiology and pathogenesis of PR have not been clarified. In recent years, researches of different aspects of PR have been made, including serologic, immunogenetic and ultrasound imaging studies, as well as the search for prognostic factors predicting the future evolution to RA. There are no controlled studies on drug therapy in PR. Acute attacks often respond well to non-steroidal anti-inflammatory drugs. Antimalarials and some disease-modifying anti-rheumatic drugs may reduce the intensity and frequency of attacks and prevent the development of RA in patients with PR.