前縱隔腔精原細胞瘤病例報告與文獻回顧

ANTERIOR MEDIASTINAL SEMINOMAS - 3 CASES REPORT AND REVIEW OF LITERATURE

謝明仁(Ming J. Hsieh) ； 乾光宇(Kwang Y. Chien) ； 張遵(Tseun Chang)

《中華放射線醫學雜誌》 8卷3期 (1983/09) Pp. 267-276

摘要

縱隔內精原細胞瘤是一不多見的疾病，其形態及組織學特徵與睪丸之原發細胞瘤是相同的。在生殖腺外產生這種原發腫瘤的致病原因，迄今尚不確定，其發生的學說仍有爭論。在臨床上的症候有完全無症狀的，或是像其他縱隔腔腫撞壓迫隣近組織器官所造成的徵象如呼吸短氣，吞嚥不舒服或以咳喇、胸痛或體重減輕等。現提出3個病例報告，並回顧有關的文獻155病案予以分析討論之。

並列摘要

Anterior mediastinal germinoma of the seminomatous type is a rare germ cell neoplasm. Of those extragonadal seminomas, the mediastinum has been by far the most common. It is widely accepted that this entity can arise primarily in the mediastinum. Three cases of the anterior mediastinal seminoma are present. All 3 cases are men with average age of 33 years. A case complained of chest distress and frequent to catch cold, and the other had body weight loss, otherwise no other specific symptoms. Radiographically these tumors appeared as lobulated mass in the mediastinum. The tumors were completely resected in 2 cases and biopsy only in one case. All cases were treated by radiation therapy after resection or biopsy. The tumors are very radiosensitive and a striking reduction in size of the tumors is noted after radiotherapy. Patients are still alive and healthy in 3,4 years follow-up. No tumor was diagnosed in the testes up to now. The previously reported 155 cases about their clinical appearance, method of treatment and long-term results as well as the histogenesis are briefly reviewed.