In CT, manifestation of neck mass mainly as low density was uncommon. We reviewed 45 cases in which CT studies revealed low density lesions in the neck. They were analyzed according to density (water, fat or air), rim enhancement and homogeneity for further differentiation. Most congenital lesions such as thyroglossal duct cyst (TGDC), branchial cleft cyst (BCC), cystic hygroma, dermoid cyst, lipoma and laryngocele were found in the midline or paramedian with or without rim enhancement. Those with heterogeneous enhancement were often of acquired etiology, such as ranula, lymphoma, neurilemmoma, parotid adenoma, metastatic nodes and tubercubus adenitis, etc.