Traditionally, the obstructed afferent loop was managed by surgical revision. Recently, percutaneous drainage tended to become an alternative for management of poor surgical candidates. We performed percutaneous transhepatic duodenal drainage to treat the obstructed afferent loop in a patient who was a poor candidate for surgery due to generalized abdominal carcinomatosis of gastric cancer and sepsis. The procedure relieved pain and abdominal distension immediately and controlled sepsis. No complication related to this procedure was found.