Extravasation of contrast media at injection site is frequently seen in daily radiologic procedures. The severity of tissue reaction to the extravasated contrast media depends on several factors: amount, osmolarity, and chemical components of contrast media. In most cases, self-limited tissue reaction occurs without consequences. Rarely, severe tissue reaction, such as skin ulceration, necrosis or compartment syndrome, may occur which require further treatment. In this article, we reviewed literatures and discussed the risks and management of contrast media extravasation. In conclusion, secure placement of venous catheters for contrast media injection is very important. Using non-ionic contrast media is suggested whenever there is risk of extravastation.