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Nonfunctioning Islet Cell Tumors of the Pancreas:Computed Tomography Findings
無功能性胰臟胰島細胞腫瘤
摘要
無功能性胰島細胞瘤，約佔所有胰島細胞瘤的15-20%。因很罕見，少有研究探討其影像發現，本研究著重在此瘤的電腦斷層影像表現。 本研究的六個病人，均接受術前電腦斷層，其中五位接受動態研究。當我們閱片時，著種在腫瘤大小、位置、邊緣、鈣化、顯影程度、同質性。惡性變化定義為影像上具有血管侵犯及轉移。手術檢體均輕免疫化學染色證實為胰島細胞瘤。 好發於年輕的病人，性別分布平均。腫瘤由二至八公分不等，平均四公分。腫瘤稍好發在胰體部和頭頸部（四例）。腫瘤邊緣規則者四例，不規則者兩例。均無鈣化。與正常胰臟組織顯影程度相比，五例有部份或全部高顯影性、二例與胰臟相似。腫瘤是非均質性四例、均質性二例。三例有惡性變化。 在電腦斷層影像檢查，無功能性胰島細胞瘤是偏向於:如腫瘤較大、邊緣平整、易中心液化、鈣化、具有高度顯影區域。或是表現類似功能性細胞瘤，為小而實心、均勻高度顯影腫瘤。
並列摘要
To review and discuss the CT features of the non-functionig islet cell tumors(NFICT) of pancreas in Veterans General Hospital in Taipei and in Taichung. The pre-operative abdominal CT of 6 cases of the nonfunctioning islet cell tumors of pancreas had been reviewed retrospectively. The pre-and post-contrast enhanced CT of abdomen was performed in a dynamic fashion for 5 patients. The other patient underwent conventional pre-and post-contrast enhanced CT of abdomen. We focused on tumor size, location, margin, calcification, enhancement pattern and homogeneity. All tumors were surgically and histopathologically proven. Malignancy was defined as liver or nodal metastasis or vessel encase-ment. Nonfunctioning islet cell tumors of pancreas occur in younger patients without gender predilec-tion. The tumor sizes ranged from 2 to 8 cm with an average size of 4 cm. The tumors are more com-monly located in pancreatic head / neck (n=4). On CT, the margin of the tumor was well-defined in 4 cases and irregular in 2 cases. No calcification in the tumors was detected. After contrast agent adminis-tration, 4 tumors were inhomogeneously better enhanced relative to the normal pancreatic parenchyma, while the other 2 did not appear to be enhanced differently. Two tumors were solid homo-geneous in consistency；whereas 4 tumors showed